| First Author | Grumont R | Year | 2004 |
| Journal | Immunity | Volume | 21 |
| Issue | 1 | Pages | 19-30 |
| PubMed ID | 15345217 | Mgi Jnum | J:93602 |
| Mgi Id | MGI:3487204 | Doi | 10.1016/j.immuni.2004.06.004 |
| Citation | Grumont R, et al. (2004) The mitogen-induced increase in T cell size involves PKC and NFAT activation of Rel/NF-kappaB-dependent c-myc expression. Immunity 21(1):19-30 |
| abstractText | Cell growth during the G1 stage of the cell cycle is partly controlled by inducing c-myc expression, which in B cells is regulated by the NF-kappaB1 and c-Rel transcription factors. Here, we show that c-myc-dependent growth during T cell activation requires c-Rel and RelA and that blocking this growth by inhibiting protein kinase C theta (PKCtheta) coincides with a failure to upregulate c-myc due to impaired RelA nuclear import and inhibition of NFAT-dependent c-rel transcription. These results demonstrate that different Rel/NF-kappaB dimers regulate the mitogenic growth of mature T and B cells, with a signaling pathway incorporating PKCtheta and NFAT controlling c-Rel/RelA-induced c-myc expression in activated T cells. |
