Primary Identifier | MGI:1856914 | Allele Type | Spontaneous |
Gene | Tshr | Inheritance Mode | Recessive |
Strain of Origin | RF/J | Is Recombinase | false |
Is Wild Type | false |
molecularNote | The mutation in the hypothyroid mouse is a C-to-T transition at coding nucleotide 1667. This results in a substitution of proline with leucine at position 556 (p.P556L) in transmembrane domain IV of the encoded protein. |