| First Author | Beamer WG | Year | 1980 |
| Journal | Mouse News Lett | Volume | 63 |
| Pages | 20 | Mgi Jnum | J:13864 |
| Mgi Id | MGI:62043 | Citation | Beamer WG, et al. (1980) Petite (pet) to hypothyroid (hyt). Mouse News Lett 63:20 |
| abstractText | Full text of MNL contribution: Change of name and gene symbol. Petite (pet) to hypothyroid (hyt). In MNL 56:41, a report was made of a recessive mutation in RF/J strain mice that caused substantial dwarfism in the homozygous condition. Allelism tests with Snell's dwarf (dw) were negative. The mutants were reported to be highly responsive in terms of body growth and reproductive activity when desiccated thyroid was administered via the diet. Subsequent studies have shown that homozygous mutants are hypothyroid by several criteria because of the failure of the thyroid to respond to pituitary thyroid stimulating hormone. The mutant gene is therefore renamed hypothyroid (hyt); its assignment to the genetic linkage map is yet to be made. (W. Beamer and Eicher) |
