| First Author | Saijoh Y | Year | 2000 |
| Journal | Mol Cell | Volume | 5 |
| Issue | 1 | Pages | 35-47 |
| PubMed ID | 10678167 | Mgi Jnum | J:60152 |
| Mgi Id | MGI:1352917 | Doi | 10.1016/s1097-2765(00)80401-3 |
| Citation | Saijoh Y, et al. (2000) Left-right asymmetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2. Mol Cell 5(1):35-47 |
| abstractText | The left-right (L-R) asymmetric expression of lefty2 and nodal is controlled by a left side-specific enhancer (ASE). The transcription factor FAST2, which can mediate signaling by TGF beta and activin, has now been identified as a protein that binds to a conserved sequence in ASE. These FAST2 binding sites were both essential and sufficient for L-R asymmetric gene expression. The Fast2 gene is bilaterally expressed when nodal and lefty2 are expressed on the left side. TGF beta and activin can activate the ASE activity in a FAST2-dependent manner, while Nodal can do so in the presence of an EGF-CFC protein. These results suggest that the asymmetric expression of lefty2 and nodal is induced by a left side-specific TGF beta-related factor, which is most likely Nodal itself. |
