| First Author | Golding JP | Year | 2004 |
| Journal | Dev Dyn | Volume | 231 |
| Issue | 4 | Pages | 795-800 |
| PubMed ID | 15499557 | Mgi Jnum | J:93818 |
| Mgi Id | MGI:3505806 | Doi | 10.1002/dvdy.20176 |
| Citation | Golding JP, et al. (2004) Mouse myotomes pairs exhibit left-right asymmetric expression of MLC3F and alpha-skeletal actin. Dev Dyn 231(4):795-800 |
| abstractText | Most muscle originates from the myotomal compartment of the somites, paired structures flanking the neural tube. Whereas vertebrate embryos show molecular and morphological asymmetry about the left-right body axis, somitic myogenesis is thought to occur symmetrically. Here, we provide the first evidence that myotome pairs are transiently left-right asymmetric, with higher expression of alpha-skeletal actin and myosin light chain 3F (MLC3F) on the left side between embryonic day 9.5-10.25. In iv mutants with situs inversus, the asymmetric expression of alpha-skeletal actin and MLC3F was inverted, showing that this process is regulated by global left-right axis cues, initiated before gastrulation. However, although left-sided identity is later maintained by Pitx2 genes, we found that Pitx2c null embryos have normal left-biased expression of alpha-skeletal actin and MLC3F. Myotome asymmetry, therefore, is downstream of the iv mutation but upstream of, or unrelated to, the Pitx2c pathway. Developmental Dynamics 231:795-800, 2004. (c) 2004 Wiley-Liss, Inc. |
