| First Author | Blondet B | Year | 1995 |
| Journal | Neurosci Lett | Volume | 183 |
| Issue | 3 | Pages | 179-82 |
| PubMed ID | 7739788 | Mgi Jnum | J:23727 |
| Mgi Id | MGI:71418 | Doi | 10.1016/0304-3940(94)11145-9 |
| Citation | Blondet B, et al. (1995) Astrocytosis in wobbler mouse spinal cord involves a population of astrocytes which is glutamine synthetase-negative. Neurosci Lett 183(3):179-82 |
| abstractText | Mice affected by the wobbler mutation are characterized by a muscular atrophy associated with motoneuron degeneration. As soon as the first clinical signs of the disease appear, reactive astrocytes, strongly glial fibrillary acidic protein (GFAP)-positive, are observed in the spinal cord grey matter. They become prevalent at all levels with disease progression. Immunostaining of glutamine synthetase (GS) shows that these reactive astrocytes are never GS-positive. The activity and protein amounts of GS remain normal in wobbler spinal cord although astrocytosis develops. Thus, gliosis in the wobbler mouse seems to involve a subpopulation of astrocytes, which is strongly GFAP-positive but GS-negative. |
