| First Author | Mitsumoto H | Year | 1993 |
| Journal | Muscle Nerve | Volume | 16 |
| Issue | 5 | Pages | 542-7 |
| PubMed ID | 8390608 | Mgi Jnum | J:14361 |
| Mgi Id | MGI:62531 | Doi | 10.1002/mus.880160517 |
| Citation | Mitsumoto H, et al. (1993) Retardation of fast axonal transport in wobbler mice. Muscle Nerve 16(5):542-7 |
| abstractText | To investigate axonal function in a model of early motor neuron disease, we examined fast and slow components of anterograde axonal transport in the less-affected hindlimb motor neurons of wobbler mice. To study the fast component (FC), we injected tritiated amino acids into the lumbar spinal cord and retrieved the sciatic nerve after 2 or 3 h. The transport distance was the extent of the plateau of labeling; regression analysis indicated that FC was 25% slower in wobbler mice than in unaffected littermates (P < 0.01). To study slow component (SC), [35S]methionine was injected. Transport distances were to the peaks of labeling for structural proteins after 2 or 3 weeks. Rates for each subcomponent (SCa and SCb) were unaffected by wobbler disease. Because the rate of retrograde FC is also unaffected (Mitsumoto et al., Muscle & Nerve 13:121-126, 1990), we conclude that wobbler disease specifically retards anterograde FC in less-affected hindlimb motor neurons, whereas all components of axonal transport are retarded in forelimb motor neurons. |
