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Publication : Exclusion of the beta-subunit of type II calmodulin kinase for the wobbler spinal muscular atrophy gene.

First Author  Bronstein JM Year  1996
Journal  Brain Res Mol Brain Res Volume  43
Issue  1-2 Pages  330-2
PubMed ID  9037549 Mgi Jnum  J:37660
Mgi Id  MGI:85051 Doi  10.1016/s0169-328x(96)00045-9
Citation  Bronstein JM, et al. (1996) Exclusion of the beta-subunit of type II calmodulin kinase for the wobbler spinal muscular atrophy gene. Brain Res Mol Brain Res 43(1-2):330-2
abstractText  The wobbler mouse (wr) is an attractive model for studying motor neuron disease but the genetic defect is unknown. The beta-subunit of calmodulin kinase II (beta-CaMK II) is a good candidate for the wr mutation because of its chromosomal localization and tissue distribution. In this report, we found normal levels of CaM KII mRNA and enzyme activity making it highly unlikely that a mutation in the beta-CaM KII gene is the cause of the wr phenotype.
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