| First Author | des Portes V | Year | 1994 |
| Journal | Neuroreport | Volume | 5 |
| Issue | 15 | Pages | 1861-4 |
| PubMed ID | 7841363 | Mgi Jnum | J:21287 |
| Mgi Id | MGI:69306 | Doi | 10.1097/00001756-199410000-00005 |
| Citation | des Portes V, et al. (1994) Early detection of mouse wobbler mutation: a model of pathological motoneurone death. Neuroreport 5(15):1861-4 |
| abstractText | The mouse recessive mutation wobbler, carried by the C57BL/6J strain, is a naturally occurring model of motoneurone death. The gene is unknown and in the absence of predictive markers, mutants have to be diagnosed by phenotypic criteria at 4 weeks after birth. We localized the wobbler gene to chromosome 11 at 0.98 +/- 1.1 cM from the glutamine synthetase (Glns) gene. A polymorphic allele of the Glns gene was then introduced into the congenic wobbler strain by intraspecific crossing. One-quarter of the offspring expressed the same phenotypic mutation as true wobbler and were detectable by PCR, as they are homozygous for the wobbler-linked Glns allele. The new mutants exhibit motoneurone degeneration despite the new genetic background. |
