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Allele : Ph patch deletion region; patch
Primary Identifier  MGI:1857106 Allele Type  Spontaneous
Gene  Ph Inheritance Mode  Semidominant
Strain of Origin  C57BL/Gr Is Recombinase  false
Is Wild Type  false
description  Repulsion double heterozygotes of Ph and the allele KitW-ct at the closely linked Kit locus (Ph +/+ KitW-ct) are more anemic than Kit heterozygotes (+ KitW-ct/+ +) alone, have significantly raised leucocyte counts, and are unduly sensitive to whole body X-irradiation, indicating that the Ph locus exerts some control over hematopoiesis (J:7216). Studies of Ph homozygous embryos suggest that Ph protein is required for normal development of non-neuronal neural crest-derived structures (J:1107) and visceral endoderm and mesoderm derivatives (J:1108).
molecularNote  A deletion region including the Pdgfra gene. Precise breakpoints have not been mapped, but does not extend into the coding sequences of the adjacent Kit gene. However, expression of Kit is altered in these mutants.
  • mutations:
  • Deletion
  • synonyms:
  • Pdgfr<Ph>,
  • Pdgfr<Ph>
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1 Feature

Trail: Allele

Genome

0 Expresses

1 Mutation Involves

Trail: Allele

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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7 Carried By

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29 Publication categories

Trail: Allele




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