| First Author | Dewal RS | Year | 2024 |
| Journal | iScience | Volume | 27 |
| Issue | 2 | Pages | 108927 |
| PubMed ID | 38327776 | Mgi Jnum | J:351260 |
| Mgi Id | MGI:7581655 | Doi | 10.1016/j.isci.2024.108927 |
| Citation | Dewal RS, et al. (2024) Transplantation of committed pre-adipocytes from brown adipose tissue improves whole-body glucose homeostasis. iScience 27(2):108927 |
| abstractText | Obesity and its co-morbidities including type 2 diabetes are increasing at epidemic rates in the U.S. and worldwide. Brown adipose tissue (BAT) is a potential therapeutic to combat obesity and type 2 diabetes. Increasing BAT mass by transplantation improves metabolic health in rodents, but its clinical translation remains a challenge. Here, we investigated if transplantation of 2-4 million differentiated brown pre-adipocytes from mouse BAT stromal fraction (SVF) or human pluripotent stem cells (hPSCs) could improve metabolic health. Transplantation of differentiated brown pre-adipocytes, termed "committed pre-adipocytes" from BAT SVF from mice or derived from hPSCs improves glucose homeostasis and insulin sensitivity in recipient mice under conditions of diet-induced obesity, and this improvement is mediated through the collaborative actions of the liver transcriptome, tissue AKT signaling, and FGF21. These data demonstrate that transplantation of a small number of brown adipocytes has significant long-term translational and therapeutic potential to improve glucose metabolism. |
