| First Author | Hande P | Year | 1999 |
| Journal | Genomics | Volume | 56 |
| Issue | 2 | Pages | 221-3 |
| PubMed ID | 10051409 | Mgi Jnum | J:53579 |
| Mgi Id | MGI:1332953 | Doi | 10.1006/geno.1998.5668 |
| Citation | Hande P, et al. (1999) Elongated telomeres in scid mice. Genomics 56(2):221-3 |
| abstractText | Severe combined immunodeficiency (scid) mice are deficient in the enzyme DNA-PK (DNA-dependent protein kinase) as a result of the mutation in the gene encoding the catalytic subunit (DNA-PKcs) of this enzyme. DNA-PKcs is a member of the phosphatidylinositol 3-kinase superfamily, which includes the human protein ATM (ataxia telangiectasia mutated) and the yeast protein Tell. Using Q-PISH (quantitative fluorescence in situ hybridization), we show here that scid mice from four different genetic backgrounds have, on average, 1.5-2 times longer telomeres than those of corresponding wild-type mice. Our results point to the possibility that DNA-PKcs may, directly or indirectly, be involved in telomere length regulation in mammalian cells. (C) 1999 Academic Press. |
