| First Author | Haks MC | Year | 1999 |
| Journal | Immunity | Volume | 11 |
| Issue | 1 | Pages | 91-101 |
| PubMed ID | 10435582 | Mgi Jnum | J:110456 |
| Mgi Id | MGI:3640250 | Doi | 10.1016/s1074-7613(00)80084-9 |
| Citation | Haks MC, et al. (1999) Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells. Immunity 11(1):91-101 |
| abstractText | Signaling through the pre-TCR is essential for early T cell development and is severely impaired in mice lacking the CD3 gamma chain of the pre-TCR. We here address the molecular mechanisms underlying this defect. Impaired pre-TCR signaling is shown to be associated with a profound increase in the number of apoptotic CD4- CD8- (DN) thymocytes. Introduction of p53 deficiency into CD3 gamma-deficient mice completely reverses the cell survival defect in CD3 gamma-deficient DN thymocytes and rescues the block in pre-T cell differentiation. In addition, the CD4+ CD8+ (DP) compartment is expanded to its normal size. These findings suggest that the pre-TCR regulates progression through the DNA-damage checkpoint of the DN to DP transition by inactivating p53. |
