| First Author | Woods NB | Year | 2006 |
| Journal | Nature | Volume | 440 |
| Issue | 7088 | Pages | 1123 |
| PubMed ID | 16641981 | Mgi Jnum | J:108380 |
| Mgi Id | MGI:3623846 | Doi | 10.1038/4401123a |
| Citation | Woods NB, et al. (2006) Gene therapy: therapeutic gene causing lymphoma. Nature 440(7088):1123 |
| abstractText | The development of T-cell leukaemia following the otherwise successful treatment of three patients with X-linked severe combined immune deficiency (X-SCID) in gene-therapy trials using haematopoietic stem cells has led to a re-evaluation of this approach. Using a mouse model for gene therapy of X-SCID, we find that the corrective therapeutic gene IL2RG itself can act as a contributor to the genesis of T-cell lymphomas, with one-third of animals being affected. Gene-therapy trials for X-SCID, which have been based on the assumption that IL2RG is minimally oncogenic, may therefore pose some risk to patients. |
