| First Author | Herz J | Year | 2021 |
| Journal | Neuron | Volume | 109 |
| Issue | 22 | Pages | 3609-3618.e9 |
| PubMed ID | 34793707 | Mgi Jnum | J:315148 |
| Mgi Id | MGI:6830559 | Doi | 10.1016/j.neuron.2021.10.022 |
| Citation | Herz J, et al. (2021) GABAergic neuronal IL-4R mediates T cell effect on memory. Neuron 109(22):3609-3618.e9 |
| abstractText | Mechanisms governing how immune cells and their derived molecules impact homeostatic brain function are still poorly understood. Here, we elucidate neuronal mechanisms underlying T cell effects on synaptic function and episodic memory. Depletion of CD4 T cells led to memory deficits and impaired long-term potentiation. Severe combined immune-deficient mice exhibited amnesia, which was reversible by repopulation with T cells from wild-type but not from IL-4-knockout mice. Behaviors impacted by T cells were mediated via IL-4 receptors expressed on neurons. Exploration of snRNA-seq of neurons participating in memory processing provided insights into synaptic organization and plasticity-associated pathways regulated by immune cells. IL-4Ralpha knockout in inhibitory (but not in excitatory) neurons was sufficient to impair contextual fear memory, and snRNA-seq from these mice pointed to IL-4-driven regulation of synaptic function in promoting memory. These findings provide new insights into complex neuroimmune interactions at the transcriptional and functional levels in neurons under physiological conditions. |
