| First Author | Simons BW | Year | 2012 |
| Journal | Dev Biol | Volume | 371 |
| Issue | 2 | Pages | 246-55 |
| PubMed ID | 22960283 | Mgi Jnum | J:190538 |
| Mgi Id | MGI:5449101 | Doi | 10.1016/j.ydbio.2012.08.016 |
| Citation | Simons BW, et al. (2012) Wnt signaling though beta-catenin is required for prostate lineage specification. Dev Biol 371(2):246-55 |
| abstractText | Androgens initiate a complex network of signals within the UGS that trigger prostate lineage commitment and bud formation. Given its contributions to organogenesis in other systems, we investigated a role for canonical Wnt signaling in prostate development. We developed a new method to achieve complete deletion of beta-catenin, the transcriptional coactivator required for canonical Wnt signaling, in early prostate development. Beta-catenin deletion abrogated canonical Wnt signaling and yielded prostate rudiments that exhibited dramatically decreased budding and failed to adopt prostatic identity. This requirement for canonical Wnt signaling was limited to a brief critical period during the initial molecular phase of prostate identity specification. Deletion of beta-catenin in the adult prostate did not significantly affect organ homeostasis. Collectively, these data establish that beta-catenin and Wnt signaling play key roles in prostate lineage specification and bud outgrowth. |
