First Author | Miller RD | Year | 1995 |
Journal | Proc Natl Acad Sci U S A | Volume | 92 |
Issue | 23 | Pages | 10792-5 |
PubMed ID | 7479885 | Mgi Jnum | J:29679 |
Mgi Id | MGI:77204 | Doi | 10.1073/pnas.92.23.10792 |
Citation | Miller RD, et al. (1995) Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus. Proc Natl Acad Sci U S A 92(23):10792-5 |
abstractText | The gene encoding the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) has been proposed recently as a candidate gene for the mouse severe combined immune deficiency (scid) locus. We have used a partial cDNA clone for human DNA-PKcs to map the mouse homologue using a large interspecific backcross panel. We found that the mouse gene for DNA-PKcs does not recombine with scid, consistent with the hypothesis that scid is a mutation in the mouse gene for DNA-PKcs. |