| First Author | Clemente-Casares X | Year | 2016 |
| Journal | Nature | Volume | 530 |
| Issue | 7591 | Pages | 434-40 |
| PubMed ID | 26886799 | Mgi Jnum | J:229667 |
| Mgi Id | MGI:5752983 | Doi | 10.1038/nature16962 |
| Citation | Clemente-Casares X, et al. (2016) Expanding antigen-specific regulatory networks to treat autoimmunity. Nature 530(7591):434-40 |
| abstractText | Regulatory T cells hold promise as targets for therapeutic intervention in autoimmunity, but approaches capable of expanding antigen-specific regulatory T cells in vivo are currently not available. Here we show that systemic delivery of nanoparticles coated with autoimmune-disease-relevant peptides bound to major histocompatibility complex class II (pMHCII) molecules triggers the generation and expansion of antigen-specific regulatory CD4(+) T cell type 1 (TR1)-like cells in different mouse models, including mice humanized with lymphocytes from patients, leading to resolution of established autoimmune phenomena. Ten pMHCII-based nanomedicines show similar biological effects, regardless of genetic background, prevalence of the cognate T-cell population or MHC restriction. These nanomedicines promote the differentiation of disease-primed autoreactive T cells into TR1-like cells, which in turn suppress autoantigen-loaded antigen-presenting cells and drive the differentiation of cognate B cells into disease-suppressing regulatory B cells, without compromising systemic immunity. pMHCII-based nanomedicines thus represent a new class of drugs, potentially useful for treating a broad spectrum of autoimmune conditions in a disease-specific manner. |
