| First Author | Meng KP | Year | 2020 |
| Journal | J Exp Med | Volume | 217 |
| Issue | 8 | PubMed ID | 32484502 |
| Mgi Jnum | J:294938 | Mgi Id | MGI:6457897 |
| Doi | 10.1084/jem.20200053 | Citation | Meng KP, et al. (2020) Mechanosensing through YAP controls T cell activation and metabolism. J Exp Med 217(8) |
| abstractText | Upon immunogenic challenge, lymph nodes become mechanically stiff as immune cells activate and proliferate within their encapsulated environments, and with resolution, they reestablish a soft baseline state. Here we show that sensing these mechanical changes in the microenvironment requires the mechanosensor YAP. YAP is induced upon activation and suppresses metabolic reprogramming of effector T cells. Unlike in other cell types in which YAP promotes proliferation, YAP in T cells suppresses proliferation in a stiffness-dependent manner by directly restricting the translocation of NFAT1 into the nucleus. YAP slows T cell responses in systemic viral infections and retards effector T cells in autoimmune diabetes. Our work reveals a paradigm whereby tissue mechanics fine-tune adaptive immune responses in health and disease. |
