| First Author | Kälin S | Year | 2017 |
| Journal | Cell Metab | Volume | 26 |
| Issue | 3 | Pages | 475-492.e7 |
| PubMed ID | 28877454 | Mgi Jnum | J:251831 |
| Mgi Id | MGI:6106904 | Doi | 10.1016/j.cmet.2017.08.008 |
| Citation | Kalin S, et al. (2017) A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function. Cell Metab 26(3):475-492.e7 |
| abstractText | Obesity and type 2 diabetes are associated with metabolic defects and adipose tissue inflammation. Foxp3(+) regulatory T cells (Tregs) control tissue homeostasis by counteracting local inflammation. However, if and how T cells interlink environmental influences with adipocyte function remains unknown. Here, we report that enhancing sympathetic tone by cold exposure, beta3-adrenergic receptor (ADRB3) stimulation or a short-term high-calorie diet enhances Treg induction in vitro and in vivo. CD4(+) T cell proteomes revealed higher expression of Foxp3 regulatory networks in response to cold or ADRB3 stimulation in vivo reflecting Treg induction. Specifically, Ragulator-interacting protein C17orf59, which limits mTORC1 activity, was upregulated in CD4(+) T cells by either ADRB3 stimulation or cold exposure, suggesting contribution to Treg induction. By loss- and gain-of-function studies, including Treg depletion and transfers in vivo, we demonstrated that a T cell-specific Stat6/Pten axis links cold exposure or ADRB3 stimulation with Foxp3(+) Treg induction and adipose tissue function. Our findings offer a new mechanistic model in which tissue-specific Tregs maintain adipose tissue function. |
