| First Author | Lehr L | Year | 2004 |
| Journal | FEBS Lett | Volume | 576 |
| Issue | 1-2 | Pages | 179-82 |
| PubMed ID | 15474034 | Mgi Jnum | J:108474 |
| Mgi Id | MGI:3624147 | Doi | 10.1016/j.febslet.2004.08.081 |
| Citation | Lehr L, et al. (2004) Control of 4E-BP1 expression in mouse brown adipose tissue by the beta3-adrenoceptor. FEBS Lett 576(1-2):179-82 |
| abstractText | Knockout of the translation inhibitor 4E-BP1 induces an overexpression of uncoupling protein-1 (UCP1) [Nature Medicine 7 (2001) 1128]. A possible inverse control of UCP1 and 4E-BP1 expressions in mouse brown adipose tissue was investigated. Cold-exposure, which increases the expression of UCP1, decreased that of 4E-BP1 mRNA in wild type but not in beta1/beta2/beta3-adrenoceptor knockout mice. Administration of the beta3-adrenoceptor agonist CL 316246 decreased 4E-BP1 mRNA by 75% and protein by 41% after 6 and 48 h, respectively. Our data are the first report of a regulation by the beta3-adrenoceptor of 4E-BP1 expression. They support a role of the latter in adaptive thermogenesis. |
