| First Author | Jimenez M | Year | 2002 |
| Journal | FEBS Lett | Volume | 530 |
| Issue | 1-3 | Pages | 37-40 |
| PubMed ID | 12387862 | Mgi Jnum | J:79769 |
| Mgi Id | MGI:2388907 | Doi | 10.1016/s0014-5793(02)03387-2 |
| Citation | Jimenez M, et al. (2002) beta(1)/beta(2)/beta(3)-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting. FEBS Lett 530(1-3):37 |
| abstractText | Catecholamines are viewed as major stimulants of diet- and cold-induced thermogenesis and of fasting-induced lipolysis, through the beta-adrenoceptors (beta(1)/beta(2)/beta(3)). To test this hypothesis, we generated beta(1)/beta(2)/beta(3)-adrenoceptor triple knockout (TKO) mice and compared them to wild type animals. TKO mice exhibited normophagic obesity and cold-intolerance. Their brown fat had impaired morphology and lacked responses to cold of uncoupling protein-1 expression. In contrast, TKO mice had higher circulating levels of free fatty acids and glycerol at basal and fasted states, suggesting enhanced lipolysis. Hence, beta-adrenergic signalling is essential for the resistance to obesity and cold, but not for the lipolytic response to fasting. |
