| First Author | Bachman ES | Year | 2002 |
| Journal | Science | Volume | 297 |
| Issue | 5582 | Pages | 843-5 |
| PubMed ID | 12161655 | Mgi Jnum | J:79309 |
| Mgi Id | MGI:2387786 | Doi | 10.1126/science.1073160 |
| Citation | Bachman ES, et al. (2002) betaAR signaling required for diet-induced thermogenesis and obesity resistance. Science 297(5582):843-5 |
| abstractText | Excessive caloric intake is thought to be sensed by the brain, which then activates thermogenesis as a means of preventing obesity. The sympathetic nervous system, through beta-adrenergic receptor (betaAR) action on target tissues, is likely the efferent arm of this homeostatic mechanism. To test this hypothesis, we created mice that lack the three known betaARs (beta-less mice). beta-less mice on a Chow diet had a reduced metabolic rate and were slightly obese. On a high-fat diet, beta-less mice, in contrast to wild-type mice, developed massive obesity that was due entirely to a failure of diet-induced thermogenesis. These findings establish that betaARs are necessary for diet-induced thermogenesis and that this efferent pathway plays a critical role in the body's defense against diet-induced obesity. |
