| First Author | Liu Y | Year | 2014 |
| Journal | Neuroscience | Volume | 257 |
| Pages | 149-57 | PubMed ID | 24215978 |
| Mgi Jnum | J:336950 | Mgi Id | MGI:6834127 |
| Doi | 10.1016/j.neuroscience.2013.10.078 | Citation | Liu Y, et al. (2014) Expression of beta1- and beta2-adrenoceptors in different subtypes of interneurons in the medial prefrontal cortex of mice. Neuroscience 257:149-57 |
| abstractText | Noradrenaline acting via beta-adrenoceptors (beta-ARs) in the CNS plays an important role in learning/memory and cognitive functions. beta-ARs have been shown to be expressed in cortical pyramidal and subcortical principal cells. However, little is known about beta-AR expression in different subtypes of GABAergic neurons. Here, we report that both beta1- and beta2-ARs are expressed in a majority of GABAergic interneurons in the medial prefrontal cortex of mice, including parvalbumin (PV)-, calretinin (CR)-, calbindin D-28k (CB)-, somatostatin (SST)- and Reelin-immunoreactive (ir) interneurons. Relative to PV-, CB-, SST- and Reelin-ir interneurons, CR-ir interneurons are less likely to express beta1- and beta2-ARs. SST-ir interneurons are more likely to express beta2-AR compared with the other subtypes of interneurons. The present results are of significance for understanding the role of beta-ARs in prefrontal cortical functions. |
