| First Author | Rahman A | Year | 2005 |
| Journal | FEBS Lett | Volume | 579 |
| Issue | 28 | Pages | 6411-6 |
| PubMed ID | 16288750 | Mgi Jnum | J:103774 |
| Mgi Id | MGI:3610708 | Doi | 10.1016/j.febslet.2005.10.024 |
| Citation | Rahman A, et al. (2005) High cholesterol diet induces tau hyperphosphorylation in apolipoprotein E deficient mice. FEBS Lett 579(28):6411-6 |
| abstractText | We analysed the effects of high cholesterol (HC) intake and reduced apolipoprotein E (apoE) activity on tau phosphorylation and on the activities of the major tau kinases and phosphatases in brains from wild-type and apoE-knockout (apoEKO) mice. We show that HC diet potently induced intraneuronal accumulation of hyperphosphorylated tau in apoEKO mice, as well as upregulation of several tau kinases, without affecting tau phosphatases. Our results suggest an interaction between dietary and genetic factors in the development of tauopathies, which can be relevant in humans, where the apoE4 isoform could have a lack of function as compared to other isoforms. |
