| First Author | Del Toro R | Year | 2016 |
| Journal | Nat Commun | Volume | 7 |
| Pages | 12706 | PubMed ID | 27586429 |
| Mgi Jnum | J:242107 | Mgi Id | MGI:5904420 |
| Doi | 10.1038/ncomms12706 | Citation | Del Toro R, et al. (2016) Nestin(+) cells direct inflammatory cell migration in atherosclerosis. Nat Commun 7:12706 |
| abstractText | Atherosclerosis is a leading death cause. Endothelial and smooth muscle cells participate in atherogenesis, but it is unclear whether other mesenchymal cells contribute to this process. Bone marrow (BM) nestin(+) cells cooperate with endothelial cells in directing monocyte egress to bloodstream in response to infections. However, it remains unknown whether nestin(+) cells regulate inflammatory cells in chronic inflammatory diseases, such as atherosclerosis. Here, we show that nestin(+) cells direct inflammatory cell migration during chronic inflammation. In Apolipoprotein E (ApoE) knockout mice fed with high-fat diet, BM nestin(+) cells regulate the egress of inflammatory monocytes and neutrophils. In the aorta, nestin(+) stromal cells increase approximately 30 times and contribute to the atheroma plaque. Mcp1 deletion in nestin(+) cells-but not in endothelial cells only- increases circulating inflammatory cells, but decreases their aortic infiltration, delaying atheroma plaque formation and aortic valve calcification. Therefore, nestin expression marks cells that regulate inflammatory cell migration during atherosclerosis. |
