| First Author | Howatt DA | Year | 2017 |
| Journal | Circ J | Volume | 81 |
| Issue | 6 | Pages | 888-890 |
| PubMed ID | 28420827 | Mgi Jnum | J:278380 |
| Mgi Id | MGI:6296145 | Doi | 10.1253/circj.CJ-17-0229 |
| Citation | Howatt DA, et al. (2017) Relaxin and Matrix Metalloproteinase-9 in Angiotensin II-Induced Abdominal Aortic Aneurysms. Circ J 81(6):888-890 |
| abstractText | BACKGROUND: This study determined whether relaxin or matrix metalloproteinase (MMP)-9 influences angiotensin II (AngII)-induced abdominal aortic aneurysms (AAA).Methods and Results:Male C57BL/6 or apolipoprotein E(-/-)mice were infused with AngII with or without relaxin. Relaxin did not influence AngII-induced AAA in either mouse strain. Infusion of AngII reduced, but relaxin increased, MMP-9 mRNA in macrophages. We then determined the effects of MMP-9 deficiency on AAA in apolipoprotein E(-/-)mice. MMP-9 deficiency led to AAA formation in the absence of AngII, and augmented AngII-induced aortic rupture and AAA incidence. CONCLUSIONS: MMP-9 deficiency augmented AngII-induced AAA. |
