| First Author | Guttenplan KA | Year | 2021 |
| Journal | Nature | Volume | 599 |
| Issue | 7883 | Pages | 102-107 |
| PubMed ID | 34616039 | Mgi Jnum | J:326213 |
| Mgi Id | MGI:7287950 | Doi | 10.1038/s41586-021-03960-y |
| Citation | Guttenplan KA, et al. (2021) Neurotoxic reactive astrocytes induce cell death via saturated lipids. Nature 599(7883):102-107 |
| abstractText | Astrocytes regulate the response of the central nervous system to disease and injury and have been hypothesized to actively kill neurons in neurodegenerative disease(1-6). Here we report an approach to isolate one component of the long-sought astrocyte-derived toxic factor(5,6). Notably, instead of a protein, saturated lipids contained in APOE and APOJ lipoparticles mediate astrocyte-induced toxicity. Eliminating the formation of long-chain saturated lipids by astrocyte-specific knockout of the saturated lipid synthesis enzyme ELOVL1 mitigates astrocyte-mediated toxicity in vitro as well as in a model of acute axonal injury in vivo. These results suggest a mechanism by which astrocytes kill cells in the central nervous system. |
