| First Author | Horsburgh K | Year | 1999 |
| Journal | Neuroreport | Volume | 10 |
| Issue | 4 | Pages | 837-41 |
| PubMed ID | 10208557 | Mgi Jnum | J:54423 |
| Mgi Id | MGI:1335276 | Doi | 10.1097/00001756-199903170-00031 |
| Citation | Horsburgh K, et al. (1999) Increased neuronal damage in apolipoprotein E-deficient mice following global ischaemia. Neuroreport 10(4):837-41 |
| abstractText | There is accumulating evidence that apolipoprotein E (apoE) plays a role in regulating the response to and outcome following brain injury. The present study compared the histological outcome and recovery following an episode of global ischaemia in apoE-deficient mice and wild-type littermates (12-week-old males, n = 8 per group). Transient global ischaemia was induced for a period of 17 min and the animals were allowed to recover for 72 h. Transient global ischaemia induced selective neuronal degeneration in several brain regions in wild-type mice. There was statistically significant increased ischaemic neuronal damage in apoE-deficient mice compared with wild-type mice in six of the seven regions examined (hippocampal regions CA1, CA3/CA4 and dentate gyrus; thalamus; cortex and caudate nucleus; P < 0.05). The data substantiate a role for apoE in modifying the response of the CNS to acute injury. |
