| First Author | Agianniotis A | Year | 2012 |
| Journal | Atherosclerosis | Volume | 223 |
| Issue | 2 | Pages | 314-20 |
| PubMed ID | 22770991 | Mgi Jnum | J:332272 |
| Mgi Id | MGI:6840340 | Doi | 10.1016/j.atherosclerosis.2012.06.014 |
| Citation | Agianniotis A, et al. (2012) Wall properties of the apolipoprotein E-deficient mouse aorta. Atherosclerosis 223(2):314-20 |
| abstractText | OBJECTIVES: We quantified the dysfunction of the aortic wall, determined structural and elastic properties, and provided histological data of the thoracic aortas of apolipoprotein E (apoE)-deficient mice which are used as model of atherosclerosis. METHODS: Six young 10-12 week-old (apoE)-deficient mice of both sexes were studied and six age-matched C57BL/6J wild-type mice were used as control group. We performed extension-inflation mechanical tests at three different axial stretches (lambda(z) = 1.6, 1.8, and 2.0), under maximally contracted or totally relaxed state of the vascular smooth muscle cells. Classical histology was performed to the arterial segments. RESULTS: Control aortas were generally more distensible than the (apoE)-deficient mouse aortas under both relaxed and contracted smooth muscle. Also, aortas from (apoE)-deficient mice were stiffer (higher incremental elastic modulus) than control aortas. Control aortas exhibited a higher active diameter response compared to (apoE)-deficient mouse aortas, despite the fact that vascular smooth muscle cell density was increased by approximately 15% in the (apoE)-deficient mouse aortas. CONCLUSION: We found substantial changes in the structural and elastic properties of the wall, in the active diameter response and in the histology of (apoE)-deficient mouse aortas compared to the control group. Our data can be used in the development of constituent-based models of the arterial wall and in studying the changes in arterial wall properties in presence of disease, such as atherosclerosis. |
