| First Author | Iwai M | Year | 2011 |
| Journal | Biochem Biophys Res Commun | Volume | 406 |
| Issue | 1 | Pages | 123-6 |
| PubMed ID | 21296052 | Mgi Jnum | J:170925 |
| Mgi Id | MGI:4947901 | Doi | 10.1016/j.bbrc.2011.02.007 |
| Citation | Iwai M, et al. (2011) Irbesartan increased PPARgamma activity in vivo in white adipose tissue of atherosclerotic mice and improved adipose tissue dysfunction. Biochem Biophys Res Commun 406(1):123-6 |
| abstractText | The effect of the PPARgamma agonistic action of an AT(1) receptor blocker, irbesartan, on adipose tissue dysfunction was explored using atherosclerotic model mice. Adult male apolipoprotein E-deficient (ApoEKO) mice at 9 weeks of age were treated with a high-cholesterol diet (HCD) with or without irbesartan at a dose of 50mg/kg/day for 4 weeks. The weight of epididymal and retroperitoneal adipose tissue was decreased by irbesartan without changing food intake or body weight. Treatment with irbesartan increased the expression of PPARgamma in white adipose tissue and the DNA-binding activity of PPARgamma in nuclear extract prepared from adipose tissue. The expression of adiponectin, leptin and insulin receptor was also increased by irbesartan. These results suggest that irbesartan induced activation of PPARgamma and improved adipose tissue dysfunction including insulin resistance. |
