| First Author | Iqbal J | Year | 2012 |
| Journal | Circ Res | Volume | 110 |
| Issue | 12 | Pages | 1575-84 |
| PubMed ID | 22556338 | Mgi Jnum | J:212657 |
| Mgi Id | MGI:5581926 | Doi | 10.1161/CIRCRESAHA.112.264283 |
| Citation | Iqbal J, et al. (2012) Increased intestinal lipid absorption caused by Ire1beta deficiency contributes to hyperlipidemia and atherosclerosis in apolipoprotein E-deficient mice. Circ Res 110(12):1575-84 |
| abstractText | RATIONALE: High fasting serum lipid levels are significant risk factors for atherosclerosis. However, the contributions of postprandial excursions in serum lipoproteins to atherogenesis are less well-characterized. OBJECTIVE: This study aims to delineate whether changes in intestinal lipid absorption associated with loss of inositol-requiring enzyme 1beta (Ire1beta) would affect the development of hyperlipidemia and atherosclerosis in Apoe(-/-) mice. METHODS AND RESULTS: We used Ire1beta-deficient mice to assess the contribution of intestinal lipid absorption to atherosclerosis. Here, we show that Ire1b(-/-)/Apoe(-/-) mice contain higher levels of intestinal microsomal triglyceride transfer protein, absorb more lipids, exhibit hyperlipidemia, and have higher levels of atherosclerotic plaques compared with Apoe(-/-) mice when fed chow and western diets. CONCLUSIONS: These studies indicate that Ire1beta regulates intestinal lipid absorption and that increased intestinal lipoprotein production contributes to atherosclerosis. |
