| First Author | Park SJ | Year | 2019 |
| Journal | Nat Commun | Volume | 10 |
| Issue | 1 | Pages | 1111 |
| PubMed ID | 30846702 | Mgi Jnum | J:276771 |
| Mgi Id | MGI:6287075 | Doi | 10.1038/s41467-019-08990-9 |
| Citation | Park SJ, et al. (2019) Imaging inflammation using an activated macrophage probe with Slc18b1 as the activation-selective gating target. Nat Commun 10(1):1111 |
| abstractText | Activated macrophages have the potential to be ideal targets for imaging inflammation. However, probe selectivity over non-activated macrophages and probe delivery to target tissue have been challenging. Here, we report a small molecule probe specific for activated macrophages, called CDg16, and demonstrate its application to visualizing inflammatory atherosclerotic plaques in vivo. Through a systematic transporter screen using a CRISPR activation library, we identify the orphan transporter Slc18b1/SLC18B1 as the gating target of CDg16. |
