| First Author | Macleod MR | Year | 2003 |
| Journal | Neuroreport | Volume | 14 |
| Issue | 2 | Pages | 215-7 |
| PubMed ID | 12598732 | Mgi Jnum | J:89866 |
| Mgi Id | MGI:3041762 | Doi | 10.1097/00001756-200302100-00011 |
| Citation | Macleod MR, et al. (2003) Reduced NMDA-induced apoptosis in neurons lacking ataxia telangiectasia mutated protein. Neuroreport 14(2):215-7 |
| abstractText | Apoptosis is an important route to neuronal death in experimental models of stroke, the leading neurological cause of death and disability. Here we explore a role for ataxia telangiectasia mutated protein (ATM), an activator of p53, in a primary cortical culture model of stroke. NMDA-induced apoptosis was reduced in cultures derived from mice with targeted deletions in the ATM gene. In addition, NMDA-induced caspase-3 activity was abolished in cultures lacking two functioning copies of the ATM gene. These data provide evidence to suggest that, in primary cortical culture, NMDA-induced apoptosis is partially mediated through ATM. They provide further evidence to support the hypothesis that DNA damage is one route to apoptosis following neuronal injury. |
