| First Author | Hori A | Year | 2024 |
| Journal | iScience | Volume | 27 |
| Issue | 5 | Pages | 109704 |
| PubMed ID | 38680663 | Mgi Jnum | J:348926 |
| Mgi Id | MGI:7625953 | Doi | 10.1016/j.isci.2024.109704 |
| Citation | Hori A, et al. (2024) MHC class I-dressing is mediated via phosphatidylserine recognition and is enhanced by polyI:C. iScience 27(5):109704 |
| abstractText | In addition to cross-presentation, cross-dressing plays an important role in the induction of CD8(+) T cell immunity. In the process of cross-dressing, conventional dendritic cells (DCs) acquire major histocompatibility complex class I (MHCI) from other cells and subsequently prime CD8(+) T cells via the pre-formed antigen-MHCI complexes without antigen processing. However, the mechanisms underlying the cross-dressing pathway, as well as the relative contributions of cross-presentation and cross-dressing to CD8(+) T cell priming are not fully understood. Here, we demonstrate that DCs rapidly acquire MHCI-containing membrane fragments from dead cells via the phosphatidylserine recognition-dependent mechanism for cross-dressing. The MHCI dressing is enhanced by a TLR3 ligand polyinosinic-polycytidylic acid (polyI:C). Further, polyI:C promotes not only cross-presentation but also cross-dressing in vivo. Taken together, these results suggest that cross-dressing as well as cross-presentation is involved in inflammatory diseases associated with cell death and type I IFN production. |
