| First Author | Basha G | Year | 2012 |
| Journal | Nat Immunol | Volume | 13 |
| Issue | 3 | Pages | 237-45 |
| PubMed ID | 22306692 | Mgi Jnum | J:181327 |
| Mgi Id | MGI:5311049 | Doi | 10.1038/ni.2225 |
| Citation | Basha G, et al. (2012) A CD74-dependent MHC class I endolysosomal cross-presentation pathway. Nat Immunol 13(3):237-245 |
| abstractText | Immune responses are initiated and primed by dendritic cells (DCs) that cross-present exogenous antigen. The chaperone CD74 (invariant chain) is thought to promote DC priming exclusively in the context of major histocompatibility complex (MHC) class II. However, we demonstrate here a CD74-dependent MHC class I cross-presentation pathway in DCs that had a major role in the generation of MHC class I-restricted, cytolytic T lymphocyte (CTL) responses to viral protein- and cell-associated antigens. CD74 associated with MHC class I in the endoplasmic reticulum of DCs and mediated the trafficking of MHC class I to endolysosomal compartments for loading with exogenous peptides. We conclude that CD74 has a previously undiscovered physiological function in endolysosomal DC cross-presentation for priming MHC class I-mediated CTL responses. |
