| First Author | Wells FB | Year | 1991 |
| Journal | Science | Volume | 253 |
| Issue | 5022 | Pages | 903-5 |
| PubMed ID | 1831565 | Mgi Jnum | J:113013 |
| Mgi Id | MGI:3664191 | Doi | 10.1126/science.1831565 |
| Citation | Wells FB, et al. (1991) Requirement for positive selection of gamma delta receptor-bearing T cells. Science 253(5022):903-5 |
| abstractText | The alpha beta and gamma delta T cell receptors for antigen (TCR) delineate distinct T cell populations. TCR alpha beta-bearing thymocytes must be positively selected by binding of the TCR to major histocompatibility complex (MHC) molecules on thymic epithelium. To examine the requirement for positive selection of TCR gamma delta T cells, mice bearing a class I MHC-specific gamma delta transgene (Tg) were crossed to mice with disrupted beta 2 microglobulin (beta 2M) genes. The Tg+beta 2M- (class I MHC-) offspring had Tg+ thymocytes that did not proliferate to antigen or Tg-specific monoclonal antibody and few peripheral Tg+ cells. This is evidence for positive selection within the gamma delta T cell subset. |
