| First Author | Grubin CE | Year | 1997 |
| Journal | Immunity | Volume | 7 |
| Issue | 2 | Pages | 197-208 |
| PubMed ID | 9285405 | Mgi Jnum | J:84193 |
| Mgi Id | MGI:2665408 | Doi | 10.1016/s1074-7613(00)80523-3 |
| Citation | Grubin CE, et al. (1997) Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides. Immunity 7(2):197-208 |
| abstractText | The role of self-peptides in positive selection of CD4+ T cells has been controversial. We show that some self-peptides are presented by the MHC class II molecule I-A(b) in mice lacking Ii or H-2M but not in mice expressing a transgene-encoded peptide fused to I-A(b). In experiments using specific antibodies to block selection, these low-abundance self-peptides were implicated in the positive selection of some CD4+ T cells in H-2M-/- mice. However, all three mutant backgrounds failed to positively select two class II-restricted transgenic T cell receptors. Our findings suggest that minor components of the self-peptide repertoire can contribute to positive selection of a significant number of CD4+ T cells. In addition, the data suggest that T cell receptor repertoires selected in wild-type mice and in mice displaying limited spectra of self-peptides are distinct. |
