| First Author | Cruz-Adalia A | Year | 2017 |
| Journal | Nat Commun | Volume | 8 |
| Issue | 1 | Pages | 1591 |
| PubMed ID | 29147022 | Mgi Jnum | J:255875 |
| Mgi Id | MGI:6106285 | Doi | 10.1038/s41467-017-01661-7 |
| Citation | Cruz-Adalia A, et al. (2017) Conventional CD4(+) T cells present bacterial antigens to induce cytotoxic and memory CD8(+) T cell responses. Nat Commun 8(1):1591 |
| abstractText | Bacterial phagocytosis and antigen cross-presentation to activate CD8(+) T cells are principal functions of professional antigen presenting cells. However, conventional CD4(+) T cells also capture and kill bacteria from infected dendritic cells in a process termed transphagocytosis (also known as transinfection). Here, we show that transphagocytic T cells present bacterial antigens to naive CD8(+) T cells, which proliferate and become cytotoxic in response. CD4(+) T-cell-mediated antigen presentation also occurs in vivo in the course of infection, and induces the generation of central memory CD8(+) T cells with low PD-1 expression. Moreover, transphagocytic CD4(+) T cells induce protective anti-tumour immune responses by priming CD8(+) T cells, highlighting the potential of CD4(+) T cells as a tool for cancer immunotherapy. |
