| First Author | Dao T | Year | 2001 |
| Journal | J Immunol | Volume | 166 |
| Issue | 5 | Pages | 3090-7 |
| PubMed ID | 11207260 | Mgi Jnum | J:76978 |
| Mgi Id | MGI:2180707 | Doi | 10.4049/jimmunol.166.5.3090 |
| Citation | Dao T, et al. (2001) Involvement of CD1 in peripheral deletion of T lymphocytes is independent of NK T cells. J Immunol 166(5):3090-7 |
| abstractText | During peripheral T cell deletion, lymphocytes accumulate in nonlymphoid organs including the liver, a tissue that expresses the nonclassical, MHC-like molecule, CD1. Injection of anti-CD3 Ab results in T cell activation, which in normal mice is followed by peripheral T cell deletion. However, in CD1-deficient mice, the deletion of the activated T cells from the lymph nodes was impaired. This defect in peripheral T cell deletion was accompanied by attenuated accumulation of CD8(+) T cells in the liver. In tetra-parental bone marrow chimeras, expression of CD1 on the T cells themselves was not required for T cell deletion, suggesting a role for CD1 on other cells with which the T cells interact. We tested whether this role was dependent on the Ag receptor-invariant, CD1-reactive subset of NK T cells using two other mutant mouse lines that lack most NK T cells, due to deletion of the genes encoding either beta(2)-microglobulin or the TCR element J alpha 281. However, these mice had no abnormality of peripheral T cell deletion. These findings indicate a novel role for CD1 in T cell deletion, and show that CD1 functions in this process through mechanisms that does not involve the major, TCR-invariant set of NK T cells. |
