| First Author | Krawczyk C | Year | 2002 |
| Journal | Immunity | Volume | 16 |
| Issue | 3 | Pages | 331-43 |
| PubMed ID | 11911819 | Mgi Jnum | J:111206 |
| Mgi Id | MGI:3653289 | Doi | 10.1016/s1074-7613(02)00291-1 |
| Citation | Krawczyk C, et al. (2002) Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Immunity 16(3):331-43 |
| abstractText | Integrin-mediated adhesion is essential for the formation of stable contacts between T cells and antigen-presenting cells (APCs). We show that Vav1 controls integrin-mediated adhesion of thymocytes and T cells to ECM proteins and ICAM1 following TCR stimulation. In a peptide-specific system, Vav1 is required for T cell adhesion to peptide-loaded APCs. Intriguingly, TCR-induced cell adhesion and aggregation of integrins occurs independent of WASP. Whereas LFA-1 and actin caps colocalize in wasp(-/-) T cells in response to TCR stimulation, loss of WASP uncouples TCR caps from actin patches. Our data reveal a novel role for Vav1 and WASP in the regulation of TCR-induced integrin clustering and cell adhesion and show that integrin and TCR clustering are controlled by distinct pathways. |
