| First Author | Lybarger L | Year | 2003 |
| Journal | Immunity | Volume | 18 |
| Issue | 1 | Pages | 121-30 |
| PubMed ID | 12530981 | Mgi Jnum | J:301255 |
| Mgi Id | MGI:6259400 | Doi | 10.1016/s1074-7613(02)00509-5 |
| Citation | Lybarger L, et al. (2003) Virus subversion of the MHC class I peptide-loading complex. Immunity 18(1):121-30 |
| abstractText | Many viral proteins modulate class I expression, yet, in general, their mechanisms of specific class I recognition are poorly understood. The mK3 protein of gamma(2)-Herpesvirus 68 targets the degradation of nascent class I molecules via the ubiquitin/proteasome pathway. Here, we identify cellular components of the MHC class I assembly machinery, TAP and tapasin, that are required for mK3 function. mK3 failed to regulate class I in TAP- or tapasin-deficient cells, and mK3 interacted with TAP/tapasin, even in the absence of class I. Expression of mK3 resulted in the ubiquitination of TAP/tapasin-associated class I, and mutants of class I incapable of TAP/tapasin interaction were unaffected by mK3. Thus, mK3 subverts TAP/tapasin to specifically target class I molecules for destruction. |
