| First Author | Freland S | Year | 2000 |
| Journal | Scand J Immunol | Volume | 51 |
| Issue | 3 | Pages | 219-23 |
| PubMed ID | 10736089 | Mgi Jnum | J:61231 |
| Mgi Id | MGI:1354591 | Doi | 10.1046/j.1365-3083.2000.00712.x |
| Citation | Freland S, et al. (2000) beta2-Microglobulin/CD8 -/- mice reveal significant role for CD8+ T cells in graft rejection responses in beta2-microglobulin -/- mice. Scand J Immunol 51(3):219-23 |
| abstractText | beta2-microglobulin (beta2m) -/- mice have often been used as a model to investigate host resistance to grafted tissues in the absence of CD8+ T cells. However, the realization that beta2m -/- mice have a small pool of CD8+ T cells imply that these cells may take part in immune responses in vivo. To directly address the role of CD8+ T cell responses in beta2m -/- mice, we introduced a CD8 null mutation into these mice. The beta2m/CD8 -/- mice and the corresponding control mice were primed, and challenged with syngeneic tumour grafts. While beta2m -/- mice readily cleared such tumour grafts, similar tumour grafts grew progressively in a dose dependent manner in the beta2m/CD8 -/- mice. The present results imply that residual CD8+ T cells in beta2m -/- mice may carry out significant biological functions, and suggest that studies using beta2m -/- mice as a model for CD8+ T cell deficiency must be regarded with some caution. |
