| First Author | Champsaur M | Year | 2010 |
| Journal | J Immunol | Volume | 185 |
| Issue | 1 | Pages | 157-65 |
| PubMed ID | 20530257 | Mgi Jnum | J:161608 |
| Mgi Id | MGI:4460033 | Doi | 10.4049/jimmunol.1000397 |
| Citation | Champsaur M, et al. (2010) Intact NKG2D-independent function of NK cells chronically stimulated with the NKG2D ligand Rae-1. J Immunol 185(1):157-65 |
| abstractText | Human tumors frequently express membrane-bound or soluble NK group 2, member D (NKG2D) ligands. This results in chronic engagement of NKG2D on the surfaces of NK and CD8(+) T cells and rapid internalization of the receptor. Although it is well appreciated that this phenomenon impairs NKG2D-dependent function, careful analysis of NKG2D-independent functions in cells chronically stimulated through NKG2D is lacking. Using a mouse model of chronic NKG2D ligand expression, we show that constant exposure to NKG2D ligands does not functionally impair NK cells and CD8(+) T cells in the context of viral infection. |
