| First Author | Bender BS | Year | 1992 |
| Journal | J Exp Med | Volume | 175 |
| Issue | 4 | Pages | 1143-5 |
| PubMed ID | 1552285 | Mgi Jnum | J:110598 |
| Mgi Id | MGI:3640714 | Doi | 10.1084/jem.175.4.1143 |
| Citation | Bender BS, et al. (1992) Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge. J Exp Med 175(4):1143-5 |
| abstractText | To investigate the role of CD8+ T lymphocytes in recovery from influenza pneumonia, we used transgenic mice either homozygous (-/-) or heterozygous (+/-) for beta 2-microglobulin (beta 2-M) gene disruption. These mice lack major histocompatibility complex-restricted class I (CD8+) T cells. We found that after challenge with a nonlethal influenza virus, the beta 2-M (-/-) mice had significantly delayed pulmonary viral clearance. Furthermore, after challenge with a more virulent influenza virus, the beta 2-M (-/-) mice had a significantly higher mortality rate than did control mice. Thus, CD8+ T cells are important in recovery from virulent influenza infections, but other host defense mechanisms can clear the respiratory tract of more benign infections. |
