| First Author | Huseby ES | Year | 2005 |
| Journal | Cell | Volume | 122 |
| Issue | 2 | Pages | 247-60 |
| PubMed ID | 16051149 | Mgi Jnum | J:264393 |
| Mgi Id | MGI:6196108 | Doi | 10.1016/j.cell.2005.05.013 |
| Citation | Huseby ES, et al. (2005) How the T cell repertoire becomes peptide and MHC specific. Cell 122(2):247-60 |
| abstractText | T cells bearing alphabeta T cell receptors (TCRs) recognize antigens in the form of peptides bound to class I or class II major histocompatibility proteins (MHC). TCRs on mature T cells are usually very specific for both peptide and MHC class and allele. They are picked out from a precursor population in the thymus by MHC-driven positive and negative selection. Here we show that the pool of T cells initially positively selected in the thymus contains many T cells that are very crossreactive for peptide and MHC and that subsequent negative selection establishes the MHC-restriction and peptide specificity of peripheral T cells. Our results also suggest that germline-encoded TCR variable elements have an inherent predisposition to react with features shared by all MHC proteins. |
