| First Author | Rakotomamonjy J | Year | 2019 |
| Journal | Int J Mol Sci | Volume | 20 |
| Issue | 2 | PubMed ID | 30642045 |
| Mgi Jnum | J:322682 | Mgi Id | MGI:6791607 |
| Doi | 10.3390/ijms20020285 | Citation | Rakotomamonjy J, et al. (2019) Brain-Derived Neurotrophic Factor Is Required for the Neuroprotective Effect of Mifepristone on Immature Purkinje Cells in Cerebellar Slice Culture. Int J Mol Sci 20(2):285 |
| abstractText | Endogenous gamma-aminobutyric acid (GABA)-dependent activity induces death of developing Purkinje neurons in mouse organotypic cerebellar cultures and the synthetic steroid mifepristone blocks this effect. Here, using brain-derived neurotrophic factor (BDNF) heterozygous mice, we show that BDNF plays no role in immature Purkinje cell death. However, interestingly, BDNF haploinsufficiency impairs neuronal survival induced by mifepristone and GABAA-receptors antagonist (bicuculline) treatments, indicating that the underlying neuroprotective mechanism requires the neurotrophin full expression. |
