| First Author | Pietzsch J | Year | 2012 |
| Journal | Proc Natl Acad Sci U S A | Volume | 109 |
| Issue | 39 | Pages | 15859-64 |
| PubMed ID | 23019371 | Mgi Jnum | J:190317 |
| Mgi Id | MGI:5448591 | Doi | 10.1073/pnas.1213409109 |
| Citation | Pietzsch J, et al. (2012) A mouse model for HIV-1 entry. Proc Natl Acad Sci U S A 109(39):15859-64 |
| abstractText | Passive transfer of neutralizing antibodies against HIV-1 can prevent infection in macaques and seems to delay HIV-1 rebound in humans. Anti-HIV antibodies are therefore of great interest for vaccine design. However, the basis for their in vivo activity has been difficult to evaluate systematically because of a paucity of small animal models for HIV infection. Here we report a genetically humanized mouse model that incorporates a luciferase reporter for rapid quantitation of HIV entry. An antibody's ability to block viral entry in this in vivo model is a function of its bioavailability, direct neutralizing activity, and effector functions. |
