| First Author | Choudhury A | Year | 2010 |
| Journal | Clin Immunol | Volume | 136 |
| Issue | 1 | Pages | 105-15 |
| PubMed ID | 20381429 | Mgi Jnum | J:160847 |
| Mgi Id | MGI:4455251 | Doi | 10.1016/j.clim.2010.03.003 |
| Citation | Choudhury A, et al. (2010) B cells require "nurturing" by CD4 T cells during development in order to respond in chronic graft-versus-host model of systemic lupus erythematosus. Clin Immunol 136(1):105-15 |
| abstractText | The murine chronic GVH (cGVH) model of SLE is induced by allo-recognition of foreign major histocompatibility complex (MHC) class II determinants. Previous studies have shown that syngeneic CD4(+) T cells are needed during B cell development in order to induce cGVH response in CD4KO mice. Our present studies show that B cells require "nurturing" by CD4 T cells through much of their ontogeny in order to respond to allo-signaling and become autoreactive. The nurturing process does not require antigen-specific cognate interactions between CD4 T cells and B cells. It is mediated by IL-4, but not IL-10, IL-6 and IFN-gamma. The CD4 T cell nurturing may be supplanted by large doses of IL-4 and/or by agonistic anti-CD40 mAb. Understanding the mechanism of this "nurturing" process may yield clues to the role of CD4 T cells in lupus and in host defense in general. |
