| First Author | Daniel D | Year | 2003 |
| Journal | J Exp Med | Volume | 197 |
| Issue | 8 | Pages | 1017-28 |
| PubMed ID | 12695493 | Mgi Jnum | J:82978 |
| Mgi Id | MGI:2656401 | Doi | 10.1084/jem.20021047 |
| Citation | Daniel D, et al. (2003) Immune Enhancement of Skin Carcinogenesis by CD4+ T Cells. J Exp Med 197(8):1017-28 |
| abstractText | In a transgenic model of multi-stage squamous carcinogenesis induced by human papillomavirus (HPV) oncogenes, infiltrating CD4+ T cells can be detected in both premalignant and malignant lesions. The lymph nodes that drain sites of epidermal neoplasia contain activated CD4+ T cells predominantly reactive toward Staphylococcal bacterial antigens. HPV16 mice deficient in CD4+ T cells were found to have delayed neoplastic progression and a lower incidence of tumors. This delay in carcinogenesis is marked by decreased infiltration of neutrophils, and reduced activity of matrix metalloproteinase-9, an important cofactor for tumor progression in this model. The data reveal an unexpected capability of CD4 T cells, whereby, proinflammatory CD4+ T cells, apparently responding to bacterial infection of dysplastic skin lesions, can inadvertently enhance neoplastic progression to invasive cancer. |
